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What's in the Box? is a mission in Marvel's Spider-Man. In the previous mission, Spider-Man managed to get the name "Dr. Isaac Delaney" from Charles Standish before Sable International stepped in. He passes this information onto Mary Jane Watson so she can dig into it. Yuriko Watanabe then contacts him to let him know a suspicious box was spotted atop a building in Hell's Kitchen.

Once accessed, a voice comes over the line that is unidentifiable, but challenges Spider-Man to find the bombs he has planted all over the city. This and other Challenge Recon Points enable players to collect Challenge Tokens.

Finding and disarming the bombs is a timed run, but they are relatively close by and in proximity to one another. Players just need to toss them in the air and then web them until they explode.

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