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Strong Connections is a mission in Marvel's Spider-Man. After an uncomfortable call with Mary Jane Watson, players are free to roam the city for a short period of time as Spider-Man before receiving an urgent call from Otto Octavius, who wants him down at the lab to participate in another test.

Once at the lab as Peter Parker, Otto has players perform a trio of power relay puzzles. Otto then tests the neural interface in tandem with his prosthetics with success. When he has trouble removing the cap, he reveals to Peter that he is suffering from a degenerative neurological condition. He swears Peter to secrecy. Further examination of the lab reveals results of his lab tests, which indicate that using the cranial implant could also alter Otto's personality.

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