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Spider-Hack is a mission in Marvel's Spider-Man. Spider-Man shares with Mary Jane Watson the demise of Isaac Delaney and also the name that Delaney ended up giving Martin Li: Morgan Michaels. Mary Jane lets him know that she dug up information that Norman Osborn and Wilson Fisk were apparently in league with each other, as Norman wanted Fisk to build him a secret lab. Spider-Man decides he needs to infiltrate Oscorp to see if he can find any further information.

Players must find and hack the security modules around the building in order to gain access. After hacking the first, the power goes out, and Sable International soldiers start crisscrossing the exterior of the building with their lights, making things more difficult. Their beams are relatively slow and easy to avoid, but once the second module is hacked, drones start flying around the building with larger lights. The third hack brings a helicopter on the scene with a searchlight. The last module is high up the building in the center of the Oscorp sign. Getting caught by the snipers, drones or helicopters will result in mission failure. Once it is hacked, Norman's office is very close by, and players can use the vent to access the building.

Once in the office, players can access Norman's computer, where they learn about Project GR-27, apparently a research project that has the potential to cure any known disease; however, the project seems to be a failure, targeting the subject's immune system. This failure is deemed "Devil's Breath" and is highly contagious. Morgan Michaels is the only one with a sample.

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