Breakthrough is the thirty-fourth main mission in Marvel's Spider-Man. Otto Octavius calls Peter Parker back to his lab for some exciting news. Once Peter arrives, he finds that the Doctor has already utilized a neural cranium implant to attach and use his prosthetic arms. When Peter examines the interface, he notices there are errors, and players will be tasked with completing a trio of circuit puzzles to set things right.
Upon completion, Peter expresses his concern to Otto that enough testing has not been done for someone to use the interface without some sort of issue. Otto becomes angry, prompting Peter to leave, and it is only after Octavius is alone that players see how much he has been affected. When the news comes on and Norman Osborn claims credit for the apprehension of Martin Li, Otto smashes the television with one of his robotic arms.