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A Fresh Start is a mission in Marvel's Spider-Man. Spider-Man calls Yuriko Watanabe and lets her know of the evidence he located at the F.E.A.S.T. shelter, as well as the possible attack by Martin Li using Devil's Breath, apparently a potential bio-weapon created by Oscorp. He also fills in Mary Jane Watson, agreeing to meet her for dinner.

Otto Octavius calls, urging Peter to return to the lab. Once there, Peter witnesses Otto fail at using prosthetics, and then players need to complete a circuit project in order to fix it. Otto announces that the next step is designing and building the neural interface, and Peter volunteers to help with the project, despite Otto's inability to pay him.

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